A Model Driven Architecture Framework for Robot Design and Automatic Code Generation

International audienceThis work presents a research and development experiment in software engineering at the IMT Mines Ales, France. The goal is to define a framework allowing a system controller to be graphically designed and its java code to be automatically generated. This framework is expected to be a support for students following the system engineering curriculum, and who have to program LEGO Mindstorms EV3 robots although they have not already been trained to concurrent Java programming. The experimental methodology focuses on learning and implementing the following paradigms: model driven design, software architecture for event driven systems and reactive system programming using JAVA threads. We present the design framework defined during this experiment, and the feedback of students who have been involved in setting up the state of the art and developing the framework

NGC 4102: High Resolution Infrared Observations of a Nuclear Starburst Ring

The composite galaxy NGC 4102 hosts a LINER nucleus and a starburst. We mapped NGC 4102 in the 12.8 micron line of [NeII], using the echelon spectrometer TEXES on the NASA IRTF, to obtain a data cube with 1.5" spatial and 25 km/s spectral, resolution. Combining near-infrared, radio, and the [NeII] data shows that the extinction to the starburst is substantial, more than 2 magnitudes at K band, and that the neon abundance is less than half solar. We find that the star formation in the nuclear region is confined to a rotating ring or disk of 4.3" (~300 pc) diameter, inside the Inner Lindblad Resonance. This region is an intense concentration of mass, with a dynamical mass of ~3 x 10^9 solar masses, and of star formation. The young stars in the ring produce the [NeII] flux reported by Spitzer for the entire galaxy. The mysterious blue component of line emission detected in the near-infrared is also seen in [NeII]; it is not a normal AGN outflow.Comment: submitted to Ap

Green tea increases anti-inflammatory tristetraprolin and decreases pro-inflammatory tumor necrosis factor mRNA levels in rats

BACKGROUND: Tristetraprolin (TTP/ZFP36) family proteins have anti-inflammatory activity by binding to and destabilizing pro-inflammatory mRNAs such as Tnf mRNA, and represent a potential therapeutic target for inflammation-related diseases. Tea has anti-inflammatory properties but the molecular mechanisms have not been completely elucidated. We hypothesized that TTP and/or its homologues might contribute to the beneficial effects of tea as an anti-inflammatory product. METHODS: Quantitative real-time PCR was used to investigate the effects of green tea (0, 1, and 2 g solid extract/kg diet) on the expression of Ttp family genes (Ttp/Tis11/Zfp36, Zfp36l1/Tis11b, Zfp36l2/Tis11d, Zfp36l3), pro-inflammatory genes (Tnf, Csf2/Gm-csf, Ptgs2/Cox2), and Elavl1/Hua/Hur and Vegf genes in liver and muscle of rats fed a high-fructose diet known to induce insulin resistance, oxidative stress, inflammation, and TNF-alpha levels. RESULTS: Ttp and Zfp36l1 mRNAs were the major forms in both liver and skeletal muscle. Ttp, Zfp36l1, and Zfp36l2 mRNA levels were more abundant in the liver than those in the muscle. Csf2/Gm-csf and Zfp36l3 mRNAs were undetectable in both tissues. Tea (1 g solid extract/kg diet) increased Ttp mRNA levels by 50–140% but Tnf mRNA levels decreased by 30% in both tissues, and Ptgs2/Cox2 mRNA levels decreased by 40% in the muscle. Tea (2 g solid extract/kg diet) increased Elavl1/Hua/Hur mRNA levels by 40% in the liver but did not affect any of the other mRNA levels in liver or muscle. CONCLUSION: These results show that tea can modulate Ttp mRNA levels in animals and suggest that a post-transcriptional mechanism through TTP could partially account for tea's anti-inflammatory properties. The results also suggest that drinking adequate amounts of green tea may play a role in the prevention of inflammation-related diseases

ISM properties in low-metallicity environments I. mid-infrared spectra of dwarf galaxies

We present new ISOCAM mid-infrared spectra of three starbursting nearby dwarf galaxies, NGC1569, IIZw40, NGC1140 and the 30Dor region of the LMC and explore the properties of the ISM in low-metallicity environments, also using additional sources from the literature. We analyse the various components of the ISM probed by the mid-infrared observations and compare them with other Galactic and extragalactic objects. The MIR spectra of the low-metallicity starburst sources are dominated by the [NeIII] and [SIV] lines, as well as a steeply rising dust continuum. PAH bands are generaly faint, both locally and averaged over the full galaxy, in stark contrast to dustier starburst galaxies, where the PAH features are very prominant and even dominate on global scales. The hardness of the modeled interstellar radiation fields for the dwarf galaxies increases as the presence of PAH band emission becomes less pronounced. The [NeIII]/[NeII] ratios averaged over the full galaxy are strikingly high, often >10. Thus, the hard radiation fields are pronounced and pervasive. We find a prominent correlation between the PAHs/VSGs and the [NeIII]/[NeII] ratios for a wide range of objects, including the low metallicity galaxies as well as Galactic HII regions and other metal-rich galaxies. This effect is consistent with the hardness of the interstellar radiation field playing a major role in the destruction of PAHs in the low metallicity ISM. We see a PAHs/VSGs and metallicity correlation, also found by Engelbracht et al. (2005) for a larger survey. Combined effects of metallicity and radiation field seem to be playing important roles in the observed behavior of PAHs in the low metallicity systems.Comment: accepted by A&

Spatially resolved stellar, dust and gas properties of the post-interacting Whirlpool Galaxy system

Using infrared imaging from the Herschel Space Observatory, observed as part of the VNGS, we investigate the spatially resolved dust properties of the interacting Whirlpool galaxy system (NGC 5194 and NGC 5195), on physical scales of 1 kpc. Spectral energy distribution modelling of the new infrared images in combination with archival optical, near- through mid-infrared images confirms that both galaxies underwent a burst of star formation ~370-480 Myr ago and provides spatially resolved maps of the stellar and dust mass surface densities. The resulting average dust-to-stellar mass ratios are comparable to other spiral and spheroidal galaxies studied with Herschel, with NGC 5194 at log M(dust)/M(star)= -2.5+/-0.2 and NGC 5195 at log M(dust)/M(star)= -3.5+/-0.3. The dust-to-stellar mass ratio is constant across NGC 5194 suggesting the stellar and dust components are coupled. In contrast, the mass ratio increases with radius in NGC 5195 with decreasing stellar mass density. Archival mass surface density maps of the neutral and molecular hydrogen gas are also folded into our analysis. The gas-to-dust mass ratio, 94+/-17, is relatively constant across NGC 5194. Somewhat surprisingly, we find the dust in NGC 5195 is heated by a strong interstellar radiation field, over 20 times that of the ISRF in the Milky Way, resulting in relatively high characteristic dust temperatures (~30 K). This post-starburst galaxy contains a substantial amount of low-density molecular gas and displays a gas-to-dust ratio (73+/-35) similar to spiral galaxies. It is unclear why the dust in NGC 5195 is heated to such high temperatures as there is no star formation in the galaxy and its active galactic nucleus is 5-10 times less luminous than the one in NGC 5194, which exhibits only a modest enhancement in the amplitude of its ISRF.Comment: 26 pages, 24 figures, Accepted for publication in Ap

Differential Immune Response to Bioprosthetic Heart Valve Tissues in the α1,3Galactosyltransferase-Knockout Mouse Model

Structural valve deterioration (SVD) of bioprosthetic heart valves (BHVs) has great clinical and economic consequences. Notably, immunity against BHVs plays a major role in SVD, especially when implanted in young and middle-aged patients. However, the complex pathogenesis of SVD remains to be fully characterized, and analyses of commercial BHVs in standardized-preclinical settings are needed for further advancement. Here, we studied the immune response to commercial BHV tissue of bovine, porcine, and equine origin after subcutaneous implantation into adult a1,3-galactosyltransferase-knockout (Gal KO) mice. The levels of serum anti-galactose a1,3-galactose (Gal) and -non-Gal IgM and IgG antibodies were determined up to 2 months post-implantation. Based on histological analyses, all BHV tissues studied triggered distinct infiltrating cellular immune responses that related to tissue degeneration. Increased anti-Gal antibody levels were found in serum after ATS 3f and Freedom/Solo implantation but not for Crown or Hancock II grafts. Overall, there were no correlations between cellular-immunity scores and post-implantation antibodies, suggesting these are independent factors differentially affecting the outcome of distinct commercial BHVs. These findings provide further insights into the understanding of SVD immunopathogenesis and highlight the need to evaluate immune responses as a confounding factor

A <i>Herschel</i> and BIMA study of the sequential star formation near the W 48A H II region

We present the results of Herschel HOBYS (Herschel imaging survey of OB Young Stellar objects) photometric mapping combined with Berkeley Illinois Maryland Association (BIMA) observations and additional archival data, and perform an in-depth study of the evolutionary phases of the star-forming clumps in W 48A and their surroundings. Age estimates for the compact sources were derived from bolometric luminosities and envelope masses, which were obtained from the dust continuum emission, and agree within an order of magnitude with age estimates from molecular line and radio data. The clumps in W 48A are linearly aligned by age (east-old to west-young): we find a ultra-compact (UC) H II region, a young stellar object (YSO) with class II methanol maser emission, a YSO with a massive outflow and finally the NH2D prestellar cores from Pillai et al. This remarkable positioning reflects the (star) formation history of the region. We find that it is unlikely that the star formation in the W 48A molecular cloud was triggered by the UC H II region and discuss the Aquila supershell expansion as a major influence on the evolution of W 48A. We conclude that the combination of Herschel continuum data with interferometric molecular line and radio continuum data is important to derive trustworthy age estimates and interpret the origin of large-scale structures through kinematic information

Oxidative Stress in Structural Valve Deterioration : A Longitudinal Clinical Study

The cause of structural valve deterioration (SVD) is unclear. Therefore, we investigated oxidative stress markers in sera from patients with bioprosthetic heart valves (BHVs) and their association with SVD. Blood samples were taken from SVD (Phase A) and BHV patients during the first 24 (Phase B1) and >48 months (Phase B2) after BHV implantation to assess total antioxidant capacity (TAC), malondialdehyde (MDA), and nitrotyrosine (NT). The results show that MDA levels increased significantly 1 month after surgery in all groups but were higher at 6 months only in incipient SVD patients. NT levels increased gradually for the first 24 months after implantation in the BHV group. Patients with transcatheter aortic valve implantation (TAVI) showed even higher levels of stress markers. After >48 months, MDA and NT continued to increase in BHV patients with a further elevation after 60-72 months; however, these levels were significantly lower in the incipient and established SVD groups. In conclusion, oxidative stress may play a significant role in SVD, increasing early after BHV implantation, especially in TAVI cases, and also after 48 months' follow-up, but decreasing when SVD develops. Oxidative stress potentially represents a target of therapeutic intervention and a biomarker of BHV dysfunctio

Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution

Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are a common genetic cause of Parkinson disease, but the mechanisms whereby LRRK2 is regulated are unknown. Phosphorylation of LRRK2 at Ser(910)/Ser(935) mediates interaction with 14-3-3. Pharmacological inhibition of its kinase activity abolishes Ser(910)/Ser(935) phosphorylation and 14-3-3 binding, and this effect is also mimicked by pathogenic mutations. However, physiological situations where dephosphorylation occurs have not been defined. Here, we show that arsenite or H2O2-induced stresses promote loss of Ser(910)/Ser(935) phosphorylation, which is reversed by phosphatase inhibition. Arsenite-induced dephosphorylation is accompanied by loss of 14-3-3 binding and is observed in wild type, G2019S, and kinase-dead D2017A LRRK2. Arsenite stress stimulates LRRK2 self-association and association with protein phosphatase 1α, decreases kinase activity and GTP binding in vitro, and induces translocation of LRRK2 to centrosomes. Our data indicate that signaling events induced by arsenite and oxidative stress may regulate LRRK2 function

Structure and algorithms for (cap, even hole)-free graphs

A graph is even-hole-free if it has no induced even cycles of length 4 or more. A cap is a cycle of length at least 5 with exactly one chord and that chord creates a triangle with the cycle. In this paper, we consider (cap, even hole)-free graphs, and more generally, (cap, 4-hole)-free odd-signable graphs. We give an explicit construction of these graphs. We prove that every such graph G has a vertex of degree at most [View the MathML source], and hence [View the MathML source], where ω(G) denotes the size of a largest clique in G and χ(G) denotes the chromatic number of G. We give an O(nm) algorithm for q-coloring these graphs for fixed q and an O(nm) algorithm for maximum weight stable set, where n is the number of vertices and m is the number of edges of the input graph. We also give a polynomial-time algorithm for minimum coloring. Our algorithms are based on our results that triangle-free odd-signable graphs have treewidth at most 5 and thus have clique-width at most 48, and that (cap, 4-hole)-free odd-signable graphs G without clique cutsets have treewidth at most 6ω(G)−1 and clique-width at most 48